Introduced to the United States in 2010, Xeomin is an FDA-approved method of treating fine lines and wrinkles. The major difference between Xeomin and Botox is this injectable does not contain a preservation protein and does not need to be refrigerated like Botox, making it easier to distribute since it is a “naked injectable”. This also means patients are less likely to become resistant to the injectable like some patients have reported after multiple injections of Botox.